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Response: Based on the comment received, we do not believe that this medical device is used to deliver a therapy to reduce postoperative pain or produce post-surgical or regional analgesia because the supporting information provided demonstrates that this therapy is used to treat chronic low back pain associated with multifidus muscle dysfunction, rather than post-operative or post-surgical or regional analgesia

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Dual-specificity phosphatase 5 (DUSP5) is an endogenous phosphatase that specifically targets ERK1/2 and is expressed at low levels in CRC cells

For some nutrients, the difference is much less, and in other cases slightly more

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